Genetic study in 50 cases of carcinoma breast: a prospective study
DOI:
https://doi.org/10.18203/2349-2902.isj20162853Keywords:
Carcinoma breast, Chromosomal aberrationAbstract
Background: Carcinoma breast is the leading cancer among urban Indian women. The main aim of our study was to focus on the chromosomal aberrations in patients of carcinoma breast.
Methods: Fifty case of carcinoma breast admitted in our institute between June 2009 to December 2011 were studied.
Results: In our study premature centromere division was seen in 50% patients while chromatid break was seen in 60% patients. 20% patients had an acenteric fragment. Break in the same locus in both the chromatids of a single chromosome i.e. chromosomal break was seen in 1 patient in 1p, 1q, 2q, 12q chromosome. Terminal deletion was seen 31 times in different chromosomes with most common being in 2q, 3q, 2p, 1q. Chromatid gap was seen in 24 chromosomes most common being in 1q, 2q, 3q, 6p while dicentric chromosomes was seen in 33.33% of patients.
Conclusions: Most common chromosome involved in chromosomal aberrations were 1q (CHTB, CHRB, CHTG); 2q ( CHRB, TER del, CHTG); 1p, 12q (CHRB); 3q (TER del).References
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